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Carver College of Medicine

Pediatric Endocrinology and Diabetes, Department of Pediatrics
The Division of Pediatric Endocrinology and Diabetes provides comprehensive services to children with various endocrine disorders including types 1 and 2 diabetes. There are over 3000 clinic visits a year to the general endocrine clinics and the division faculty follow over 700 patients with diabetes on a regular basis. Care is provided at the Children’s Hospital of Iowa, University of Iowa Hospitals and Clinics, in Iowa City, as well as at outreach clinics around the state of Iowa. The division has six board certified Pediatric Endocrinologists that include Eva Tsalikian,M.D. Division Director, Michael Tansey,M.D., Andrew Norris,M.D. PhD, Liuska Pesce,M.D., Katie Larson Ode,M.D. and Vanessa Curtis,M.D. Complementing the division faculty are nurses Jeanne Sheetz RN CDE, Sue Huff RN CDE, Amy Sheetz, RN CDE, Mavis Rike RN, and Julie Osterhaus ARNP. Also available are social services, dietitians, physical therapy and pediatric psychology personnel. The Division is the major provider of care to children with diabetes in the State. Outpatient clinics are held daily. In addition to the clinical personnel, Julie Coffey, ARNP is a research coordinator and Joanne Cabbage and Sarah Salamati are research assistants. The latter three members have been involved in all our clinical studies in children with diabetes including the studies that have created the preliminary data in the present application.

The division faculty members are involved in various research projects in the areas of diabetes and metabolism, molecular genetics, and the cognitive and behavioral impact of diabetes. We have been a clinical site for the Diabetes Research in Children Network (DirecNet) since 2001 continuously. In addition we have been an affiliate site for DPT-1 and Type 1 Diabetes TrialNet since 1994 and we were one of the ten sites for the JDRF continuous glucose monitor studies 2006-2008. Presently we are also a site for the NIH funded Immune Tolerance Network (ITN) with a subcontract from UCSF.

University of Iowa Clinical Research Unit
CTSA Clinical Research Unit is located on the second floor of the Boyd Tower; it consists of 20,000 square feet of recently renovated state-of-the-art clinical research facilities, and houses the clinical research facilities of the NCRR-funded Clinical and Translational Science Award. Resources include inpatient rooms (9 beds), exam rooms, consultation rooms, procedure room, infusion suite, metabolic kitchen, specimen processing area and dedicated laboratory, and clinical research cores. The CRU is staffed 24 hours/day by 10 research nurses and other appropriate personnel.

Magnetic Resonance Research Facility (MRRF) Resources
The MRRF has scanners located in both the hospital and research buildings on the campus of the University of Iowa. The MRRF contains numerous workstations for image processing and display. All are equipped with image analysis software that can be applied flexibly to all manner of research studies. The facility computers are also networked to the bioinformatics and computer resources of the Institute for Clinical and Translational Science (ICTS). The ICTS hosts their own extensive RAID server and PACS system (XNAT) to accept data from the research facility and securely share this data among collaborating users.

Neurocognitive Testing at the University of Iowa Children’s Hospital
The University of Iowa Children’s Hospital has several services that provide comprehensive neurocognitive testing for children and youth. Psychologists at the Center for Disabilities and Development also are available to carry out neurocognitive assessments for a range of neurodevelopmental disabilities (including intellectual disabilities, learning disabilities, attention deficit disorders, and autism spectrum disorders). Neuropsychological evaluations at the UI Children’s Hospital typically include comprehensive assessment of cognitive and behavioral functions using a set of standardized tests and procedures designed to define a child’s specific cognitive strengths and weaknesses. Neurocognitive tests are available to evaluate intelligence, problem solving, language, visual-spatial perception, attention, and executive functioning. This information is used to define neurobehavioral problems requiring intervention and to design strategies to overcome these problems.